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Cartilage PLUS 250/200mg
Cartilage PLUS is a dietary supplement used to help manage osteoarthritis in areas such as the knee, hip, spine, and hand. It can also be beneficial in conditions like rheumatoid arthritis, sports injuries, migraines, various skin disorders (such as psoriasis), vascular issues (like atherosclerosis), kidney stones, and inflammatory bowel conditions (e.g., ulcerative colitis and leaky gut syndrome).
(Use this medication only as advised by a registered physician.)
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✅ Description:
Glucosamine, a naturally occurring amino-sugar in the body and some foods, is a foundational component in the synthesis of glycosaminoglycans (GAGs) like Hyaluronic Acid, Keratan Sulfate, and Chondroitin Sulfate. These GAGs bind with proteins to form proteoglycans, which are crucial for building articular cartilage. Osteoarthritis can develop when cartilage in a joint degenerates. Glucosamine also supports the development of tendons, ligaments, nails, and other connective tissues. Supplementing with Glucosamine Sulfate increases glucosamine levels, supporting cartilage repair and production. Additionally, it activates chondrocytes within cartilage to produce GAGs and proteoglycans.
Chondroitin Sulfate, another GAG found in connective tissue, especially articular cartilage, provides material for proteoglycans. It protects healthy cartilage from deterioration by inhibiting the Matrix Metalloproteinase (MMP) enzyme, which breaks down proteoglycans.
Combining Glucosamine with Chondroitin Sulfate enhances efficacy, with data showing significant benefits in osteoarthritis cases, addressing symptoms and potentially slowing disease progression. This combination can prevent osteoarthritis in healthy adults and is as effective as NSAIDs for osteoarthritic pain with better tolerability. It also aids in repairing musculoskeletal soft tissue injuries, such as strains in tendons or ligaments.
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✔️ Dosage & Administration
- 250/200 mg tablets: 1–2 tablets, three times a day. Dosage adjustments may be needed based on individual response and body weight. After 60 days, doses may be reduced for individual needs and cost savings.
- Below 54 kg: 1000 mg Glucosamine Sulfate and 800 mg Chondroitin Sulfate daily.
- 54–91 kg: 1500 mg Glucosamine Sulfate and 1200 mg Chondroitin Sulfate daily.
- Above 91 kg: 2000 mg Glucosamine Sulfate and 1600 mg Chondroitin Sulfate daily.
- 750/600 mg tablets: 1 tablet twice daily or as directed by a physician.
(Use this medication only as advised by a registered physician.)
✔️ Interactions
No significant interactions have been reported between Glucosamine and Chondroitin and other common drug categories like antibiotics, antidepressants, antihypertensives, nitrates, antiarrhythmics, anxiolytics, hypoglycemics, antisecretives, and anti-asthmatics. Chondroitin may enhance the blood-thinning effects of anticoagulants like Warfarin and Heparin.
✔️ Contraindications
No contraindications are known for Glucosamine and Chondroitin except in individuals with known hypersensitivity to shellfish or sulfur.
✔️ Side Effects
Studies indicate that Glucosamine and Chondroitin are generally safe and have no notable side effects. Mild, reversible gastrointestinal symptoms (such as flatulence) are rare and similar to placebo responses.
✔️ Pregnancy & Lactation
It is advised that women who are pregnant or may become pregnant avoid Glucosamine and Chondroitin supplementation due to insufficient research on their effects on a developing fetus. Use during pregnancy or lactation should only occur with medical advice and caution.
✔️ Precautions & Warnings
Diabetic patients should monitor blood glucose levels regularly when taking Glucosamine. No specific studies exist for those with renal or hepatic impairment, though the toxicological profile does not suggest limitations for these patients. However, patients with severe renal or hepatic insufficiency should use it under medical supervision. Glucosamine and Chondroitin are not recommended for children.
✔️ Storage Conditions
Store in a cool, dry place away from light.
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